The CyBi^®-CrystalCreator is CyBio's Workstation for protein crystallization automates various protein crystallization methods for sitting drop and hanging drop efficiently and reliable, with fast and precise pipetting. The combination of a 96- and an 8-channel pipettor on a circular 10-place deck assures sufficient space for crystallization plates and reagent reservoirs. Its extended volume range from 0.1 – 25 µL as well as its flexible and user-friendly software guarantees problem-free application execution. This flexible platform allows automation of the entire process of protein crystallization process from screening to optimization and scale-up.